Klf4 and mitophagy

Author: vhuf

August undefined, 2024

WebMitophagy serves as a key cellular quality control mechanism involving sequestration of damaged mitochondria within autophagosomes and their subsequent degradation in lysosomes. However, it remains largely unknown whether mitophagy is involved in the regulation of energy metabolism in neurons, and if so, whether metabolic deficiency in AD … WebTNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.

NAD + metabolism, stemness, the immune response, and cancer

WebJan 1, 2024 · In this study, we sought to identify a mechanistic connection between KLF4 and mitophagy. Using flow cytometry, we found that Klf4 -null MEFs have diminished … WebTitle from home page (viewed Nov. 26, 2003). Latest issue consulted: Vol. 1,《Cell Communication and Signaling : CCS》2024年Volume 16共发表100篇文献，掌桥科研收录2003年以来所有《Cell Communication and Signaling : CCS》期刊内所有文献。 brazucas kodi

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http://med.wanfangdata.com.cn/Periodical/Issue?id=0370320&year=2024&issue=124-1 WebJan 9, 2024 · Conclusion: ATPIF1 maintains the normal structure of mitochondria, inhibiting the activation of mitophagy and other signaling pathway in endothelial cells. Loss of … WebDownload scientific diagram Addition of Bnip3 to Klf4-null cells rescues defects in mitophagy. (A) MEFs were transfected with either GFP control or Bnip3-myc, treated with BafA for 12 h, and ... brazuca sarasota

ATPIF1 maintains normal mitochondrial structure which …

Scilit Article - Cells deficient for Krüppel-like factor 4 exhibit ...

WebMar 1, 2024 · Open access. •. Sirt6 can promote autophagy in endothelial cells treated with AGE. •. Sirt6 exerts this autophagy-promotion function by KLF4 in endothelial cells treated with AGE. •. Sirt6 directly regulates KLF4. •. Sirt6 induces more autophagosomes formation in endothelium of STZ-induced diabetic mice. WebHere, using human glioblastoma cells, we investigated KLF4’s effects on cancer cell metabolism. We found that forced KLF4 expression promotes mitochondrial fusion and … taevakehadWebAug 4, 2015 · KLF4 serves as a critical transcriptional regulator of mitochondrial homeostasis in the heart through (i) cooperation with the ERR/PGC-1 transcriptional … brazuca shop

"WebKLF4 in cardiac cells inhibited promoter transactivation of mitochondrial DNA. The accumulation of fragmented mitochondria in KLF4-deficient cardiac cells warranted further investigation. An outstanding question that remained was whether KLF4 loss-of-function handicaps the process of autophagy. Indeed, KLF4 regulates genes involved in " - Klf4 and mitophagy

Klf4 and mitophagy

WebApr 12, 2024 · Download Citation Transcriptional regulation of autophagy and its implications in human disease Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining cell ... WebDec 5, 2024 · In this study, we sought to identify a mechanistic connection between KLF4 and mitophagy. Using flow cytometry, we found that Klf4-null MEFs have …

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WebMay 26, 2024 · Autophagy contributes to the maintenance of intracellular homeostasis in most cells of cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth muscle cells. Mitophagy is an autophagic response that specifically targets damaged, and hence potentially cytotoxic, mitochondria. As these organelles occupy a … WebApr 25, 2024 · Treatment of smooth muscle cells with porcine pancreatic elastase or interleukin (IL)-1 β activated autophagy-related genes in vitro while treatment with a siRNA to Kruppel-like transcription factor 4 ( Klf4 ), Kruppel-like transcription factor 2 ( Klf2) or Zinc-finger protein 148 ( Zfp148) separately inhibited activation of autophagy genes.

WebDec 9, 2024 · Mechanistically, Klf4 deficiency aggravated mitochondrial apoptosis, reduced ATP generation and boosted ROS overproduction via enhancing DRP1-dependent mitochondrial fission. ROCK1 was identified as a kinase regulating DRP1 activity at Ser616. WebFeb 19, 2024 · It is well-known that atherogenesis is a complex multi-component process that includes lipid metabolism disorders, inflammation, oxidative stress, autophagy disorders and mitochondrial dysfunction. Autophagy is a cellular control mechanism that is critical to maintaining health and survival.

WebMitophagy plays an important role in maintaining mitochondria ... Klf4 and c-Myc, is sufficient to reverse-differentiate fibroblasts into pluripotent stem cells (22). Interestingly, recent studies have reported that the transi-tion of mitochondrial restructuring and energy metabolism are Webby selective autophagy – or mitophagy – which degrades defective mitochondria via the lysosomal machinery. The ... KLF4, and c-MYC) are suffi-cient to reprogram differentiated somatic cells into ESC-like cells, designated as iPSCs, shifted the paradigm of unidirection-al cellular development and cell fate. The idea of reprogram-

WebMay 9, 2024 · Mitophagy is a process of selectively degrading damaged mitochondria under mitochondrial toxicity conditions, which plays an essential role in mitochondrial quality control. The abnormal...

WebMitophagy plays an important role in maintaining mitochondria ... Sox2, Klf4 and c-Myc, is sufficient to reverse-differentiate fibroblasts into pluripotent stem cells (22). Interestingly, recent ... brazucasptWebJan 1, 2024 · We found that KLF4 plays an integral role in the ability of cells to recover from mitochondrial damage. We demonstrated that one mechanism through which KLF4 performs this function is by promoting the transcription of Bnip3, a protein which targets autophagosomes to damaged mitochondria, facilitating mitophagy. taeとはWebSep 23, 2024 · KLF4 binding during reprogramming induces chromatin opening and precedes enhancer and gene activation. We mapped the genome-wide KLF4 binding at different stages of reprogramming using ... brazu casinoWebThis genomic instability can be corrected by reintroduction of KLF4 into MEFs lacking KLF4 [17]. Recently, KLF4 has been found to regulate mitophagy and mitochondria dynamics, indicating a... taev vkwWebMar 9, 2024 · Mitophagy, a special form of autophagy occurring in the mitochondrion, is a crucial process that can selectively remove superfluous or dysfunctional mitochondria, to maintain mitochondrial quality and function [ 34 ]. brazucas para kodiWebDec 10, 2024 · In the lung, KLF4 has been implicated in the normal perinatal accumulation of myofibroblasts as Klf4(−/−) neonates lack alveolar myofibroblasts, and expression of … tae vs teWebDec 1, 2024 · Our findings suggest that in Klf4-null cells, decreased Bnip3 expression impairs mitophagy and is associated with increased mitochondrial ROS production after … brazuca stremio