How does daptomycin cause myopathy

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August undefined, 2024

WebMar 1, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry stools bladder pain bloody or cloudy urine blurred vision chest pain, discomfort, or tightness chills confusion cough decreased awareness or responsiveness http://neuromuscular.wustl.edu/mother/myotox.htm

Rhabdomyolysis during therapy with daptomycin - PubMed

WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly. NOTE: This is the Professional Version. WebMar 1, 2024 · Muscle problems (eg, myopathy, rhabdomyolysis) or. Nerve problems (eg, neuropathy)—Use with caution. May make these conditions worse. Hereditary fructose intolerance (HFI), known or suspected—Dapzura RT should not be used in patients with this condition. This medicine contains sorbitol, which can cause serious side effects in … import data from excel to python

Daptomycin Injection: MedlinePlus Drug Information

WebDec 19, 2024 · In this retrospective, case-control study, both myopathy and rhabdomyolysis were increased by coadministration. Daptomycin has been associated with clinical myopathy in 2% to 14% of patients. Similarly, statins are associated with myopathy in 5% to 10% of patients. Although prior reports suggested no increased risk for myopathy when … WebDaptomycin can cause skeletal muscle myopathy with elevations in CPK. The percentage of patients treated with daptomycin in phase III trials who experienced muscle pain or … WebConclusion: Daptomycin can be associated with elevations in CPK level and rhabdomyolysis despite reduction of dose. A baseline CPK level before starting … import data from excel to powerapps

Daptomycin Monograph for Professionals - Drugs.com

WebAn endocrine myopathy is a myopathy caused by issues with the endocrine system, which controls hormone production. Endocrine myopathies can be caused by thyroid or adrenal diseases. Infectious... WebApr 1, 2005 · Although statins could theoretically increase the risk of daptomycin myopathy via additive effects, 34 patients in clinical trials received concomitant statin or fibrate … literature on human traffickingWebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant … import data from ie to edge

"WebMar 1, 2024 · Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream (bacteremia), including right-sided infective endocarditis. Daptomycin belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. " - How does daptomycin cause myopathy

How does daptomycin cause myopathy

Toxic Myopathies - Washington University in St. Louis

WebDaptomycin injection comes as a powder to be added to fluid and injected into a vein by a doctor or nurse. It is usually given once a day. The length of your treatment depends on … WebOct 15, 2024 · Background: Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated myopathy are poorly defined, creatine phosphokinase (CPK) monitoring and temporary discontinuation of 3-hydroxy-3-methylglutaryl coenzyme A …

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WebDoses more than 8 mg/kg IV every 24 hours increase the risk of CPK elevations and myopathy. Use clinical judgment and frequent monitoring if pursuing doses of 10 to 12 mg/kg IV every 24 hours in patients receiving an UFR of at least 3 L/hour. Pediatric patients†. 8 mg/kg/dose IV every 48 hours. Hybrid hemodialysis†. WebClinically relevant plasma concentrations of daptomycin reported to cause a significant concentration-dependent false prolongation of prothrombin time (PT) and elevation of International...

WebPatients often have muscle stiffness or weakness. Myositis: This is a type of myopathy that causes inflammation of your muscles, leading to weakness, swelling and pain. Many people with a myopathy, including myositis, manage their symptoms and lead active lives. Medications can often relieve symptoms. WebMar 10, 2024 · Myopathy, defined as muscle aching or muscle weakness, in conjunction with increased serum CK concentrations up to 10 times ULN reported in patients receiving daptomycin. ... Daptomycin causes concentration-dependent false prolongation of the PT and elevated INR if certain recombinant thromboplastin reagents are used for these tests.

WebDaptomycin has excellent coverage against gram-positive bacteria. The adverse effect profile has included rare reports of myopathy and elevated CK levels. Daptomycin is a … Weba disease with shrinking and weaker muscles called myopathy atrial fibrillation atrial flutter supraventricular arrhythmias, a type of abnormal heart rhythm pneumonia with high amount of...

WebMar 21, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry …

WebSep 1, 2006 · Several clinical studies and case reports have examined the possible causes and options for controlling myopathy. Unlike other causes of myopathy, daptomycin-associated myotoxicity appears to be specific for skeletal muscle. 4 No myofiber lesions … A New Rotavirus Vaccine. Abstract & Commentary. By Hal B. Jenson, MD, … import data from excel to snowflakeWebMar 7, 2024 · Cubicin may cause serious side effects including: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose), … literature on beautyWebWhile the statins are effective in providing protection from coronary and cardiovascular events, they are known to cause myopathy (usually dose-related) and, rarely, rhabdomyolysis. 1 A clinical diagnosis of myopathy is made when there is muscle pain or weakness accompanied by a creatine kinase (CK) level more than ten times the upper … literature on takeaway safetyWebJan 28, 2024 · new or worsening cough , fever, trouble breathing, unexplained muscle pain, tenderness, and. weakness. Rare side effects of Daptomycin include: none. This is not a … literature on csr software flowchartWebComment: Coadministration of daptomycin with HMG-CoA reductase inhibitors may increase CPK levels and risk for myopathy; consider temporary suspension of HMG-CoA … import data from firefox to microsoft edgeWebIn terms of adverse reactions, daptomycin is known to cause elevations in creatine kinase and myopathy, though this rarely leads to rhabdomyolysis, additionally, long-term use may cause allergic pneumonitis (Beauduy & Winston, 2024a; Macdougall, 2024b ). View chapter Purchase book Recommended publications Essentials of Neuroanesthesia Book • 2024 literature on evaluability assessmentWebApr 2, 2024 · Cardiomyopathy (kahr-dee-o-my-OP-uh-thee) is a disease of the heart muscle that makes it harder for the heart to pump blood to the rest of the body. Cardiomyopathy can lead to heart failure. The main types of … literature only