WebApr 21, 2024 · We independently prepared Bobcat339 in our laboratory and observed that it had minimal inhibitory activity against human TET1 and TET2 via a quantitative LC-ESI … WebS1 Small molecule inhibitors of TET dioxygenases: Bobcat339 activity is mediated by contaminating copper (II) Nicholas A. Weirath 1, Alexander K. Hurben1, Christopher Chao , Suresh S. Pujari , Tao Cheng2, Shujun Liu2, Natalia Y. Tretyakova*1 1Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, 2231 6th …
Bobcat339 HCl CAS#2280037-51-4 TET inhibitor MedKoo
WebMar 20, 2007 · (Stellar MLS) 2 beds, 1.5 baths, 740 sq. ft. house located at 20339 Bobcat Rd, ALTOONA, FL 32702 sold for $65,100 on Mar 20, … WebNov 12, 2024 · We hypothesized that cell-permeable 2HG and Bobcat339 would synergize to block TET activity in DIPG, restore epigenetic-balance by increasing genomic methylation, and induce cell-death. 2HG induced apoptosis in DIPG cells at concentrations ranging from 100-300uM, as measured by cleaved-PARP western and cleaved-caspase3 … ref ot
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WebBobcat 339 is a cytosine derivative that was originally found to be an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC 50 s = 33 and 73 µM, … WebJan 1, 2024 · Bobcat339 hydrochloride: Nonnucleoside analogue: A selective cytosine-based TET enzyme inhibitor which reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function: SGI-1027: Nonnucleoside analogue: Inhibits DNA methylation by directly inhibiting DNMTs, and results in selective degradation of DNMT1: WebBobcat339 is a cell penetrant, potent and selective inhibitor of TET1 and TET2 [Ten-eleven translocation methylcytosine dioxygenase (TET) 1 and 2] that reduces content of 5-hydroxymethyl-cytosine (5hmC) in cultured neurons. Bobcat339 does not inhibit DNMT3a. Safety Information. Storage Class Code. refo testzentrum bad friedrichshall